Thin-Shelled PEGylated Perfluorooctyl Bromide Nanocapsules for Tumor-Targeted Ultrasound Contrast Agent
نویسندگان
چکیده
منابع مشابه
Phospholipid decoration of microcapsules containing perfluorooctyl bromide used as ultrasound contrast agents.
We present here an easy method to modify the surface chemistry of polymeric microcapsules of perfluorooctyl bromide used as ultrasound contrast agents (UCAs). Capsules were obtained by a solvent emulsification-evaporation process with phospholipids incorporated in the organic phase before emulsification. Several phospholipids were reviewed: fluorescent, pegylated and biotinylated phospholipids....
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A folate-polyethylene glycol-chitosan derivative was synthesized and its structure was characterized. An optimal perfluorooctyl bromide nanocore template was obtained via utilizing the ultrasonic emulsification method combining with orthogonal design. The targeted nanoparticles containing targeted shell of folate-polyethylene glycol-chitosan derivative and perfluorooctyl bromide nanocore templa...
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OBJECTIVE To prepare arginine-glycine-aspartate (RGD)-targeted ultrasound contrast microbubbles (MBs) and explore the feasibility of their use in assessing dynamic changes in αvβ3 integrin expression in a murine model of tumor angiogenesis. METHODS RGD peptides were conjugated to the surfaces of microbubbles via biotin-avidin linkage. Microbubbles bearing RADfK peptides were prepared as contr...
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Encapsulated gas microbubbles, known as contrast agents, are widely used in ultrasound medical applications. The present study is devoted to modelling of the spatio-temporal dynamics of lipid-shelled contrast agents. A theoretical model is proposed that describes the radial and translational motion of a lipid-shelled microbubble in an ultrasound field. The model approximates the behaviour of th...
متن کاملExcitation of polymer-shelled contrast agents with high-frequency ultrasound.
Few experimental and complementary theoretical studies have investigated high-frequency (>20 MHz) nonlinear responses from polymer-shelled ultrasound contrast agents. Three polymer agents with different shell properties were examined for their single-bubble backscatter when excited with a 40 MHz tone burst. Higher-order harmonic responses were observed for the three agents; however, their occur...
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ژورنال
عنوان ژورنال: Contrast Media & Molecular Imaging
سال: 2018
ISSN: 1555-4309,1555-4317
DOI: 10.1155/2018/1725323